Biography: Rui Gong, Ph.D. Currently serves as a Research Assistant Professor at the Faculty of Synthetic Biology, Shenzhen University of Advanced Technology. Primary research focus is on disease diagnosis and treatment based on synthetic biology technologies. 1) Integrating synthetic biology, biosensing, and electrochemical techniques to develop ultra-sensitive sensors, thereby improving the sensitivity and accuracy of disease diagnosis; 2) Advancing precise tumor treatment strategies through research in synthetic biology, nanobiology, and cellular regulatory networks. As first author (including co-first) and corresponding author inJ. Am. Chem. Soc.、Nano Lett.、ACS Catal.、Sci. China Life Sci., Biosens. Bioelectron.、Chem. Sci.and other high-level academic journals, with more than 10 papers published.

Educational Background

2018-2021, Institute of Biophysics, Chinese Academy of Sciences, Ph.D.

2014-2018, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Master

2010-2014, Shandong Agricultural University, Bachelor

Professional Experience

2024-Present, Research Assistant Professor at the Faculty of Synthetic Biology, Shenzhen University of Advanced Technology

2022-2024, Postdoctoral Fellow, Shenzhen Second People's Hospital/ Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

Major Research Projects

1.Youth Project from the National Natural Science Foundationof China, Ongoing, Principal investigator;

2.Postdoctoral Youth Fund General Project, completed, principal investigator;

3.Guangdong Youth Fund Project, ongoing, principal investigator;

4.Shenzhen Basic Research Key Project, key member, ongoing;

5.Shenzhen "Three Famous Project," ongoing, core member;

6.Guangzhou National Laboratory Special Project, ongoing, participant.

Representative Publications:

1. Gong Rui; Yang Decai; Zhang Cuijuan; Abbas Ghulam; Miao Beiping; Liang Yueyue; Xu Jianing; Fang Xueyang; Ding Hui; NIR-II Light-Driven Multifunctional Nanozymes PS@CS for Efficient Therapy against Melanoma and Post-tumor Surgery Infection, Nano Letters, 2024.

2. Fang Xueyang; Gong Rui; Yang Decai; Li Chenxi; Zhang Yuanyuan; Wang Yan; Nie Guohui; Li Mingle; Peng Xiaojun; Zhang Bin; NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma, Journal of the American Chemical Society, 2024.

3. Song Jin; Gong Rui; Song Shibo; Abbas Ghulam; Ma Yaohong; Li Yiwei; The Value of Electrochemical Ratiometry in Immunosensing: A Systematic Study, Biosensors and Bioelectronics, 2025.

4. Wang Jie; Gong Rui; Yang Ming; Wu Xi; Li Ziwei; Huang Haibing; Yan Xiyun; Wang Daji; A Ruthenium Single Atom Nanozyme-Based Antibiotic for the Treatment of Otitis Media Caused by Staphylococcus Aureus, Frontiers in Chemistry, 2024.

5. Li Ziwei; Gong Rui; Abbas Ghulam; Feng Xiaozhou; Wang Xiaonan; Wang Jie; Huang Haibing; Han Jinghong; Zhang Bairu; Nie Guohui; Dual Phase-Conversion Strategy Reinforced Otitis Media Therapy Using Metastable Iron Sulfide-Loaded Thermosensitive Hydrogel, Advanced Therapeutics, 2023.

6. Gong Rui; Yang Chenyang; Abbas Ghulam; Wang Dianbing; Zhang Xianen; Nie Guohui; Ding Hui; Diagnosis of Nasopharyngeal Carcinoma Using an Ultrasensitive Immunoassay Method Based on Nanoparticles, Nanoscale, 2023.

7. Gong Rui; Wang Dianbing; Abbas Ghulam; Li Shimin; Liu Qian; Cui Mengmeng; Zhang Xian-En; A Switch-On Molecular Biosensor for Detection of Caspase-3 and Imaging of Apoptosis of Cells, Science China Life Sciences, 2022.

8. Yao Peiyuan; Cong Peiqian; Gong Rui; Li Jinlong; Li Guangyue; Ren Jie; Feng Jinhui; Lin Jianping; Lau Peter C. K.; Wu Qiaqing; Zhu Dunming; Biocatalytic Route to Chiral 2-Substituted-1,2,3,4-Tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins, ACS Catalysis, 2018.

9. Gong Rui; Yao Peiyuan; Chen Xi; Feng Jinhui; Wu Qiaqing; Lau Peter C. K.; Zhu Dunming; Accessing D-Valine Synthesis by Improved Variants of Bacterial Cyclohexylamine Oxidase, ChemCatChem, 2018.

10. Li Guangyue; Yao Peiyuan; Gong Rui; Li Jinlong; Liu Pi; Lonsdale Richard; Wu Qiaqing; Lin Jianping; Zhu Dunming; Reetz Manfred T.; Simultaneous Engineering of an Enzyme's Entrance Tunnel and Active Site: The Case of Monoamine Oxidase MAO-N, Chemical Science, 2017.

Utilizing cutting-edge technologies in synthetic biology, biosensing, nanobiology, and cell biology to tackle key challenges in disease diagnosis and treatment.