Dr. Liwei Xie is a Tenured Associate Professor at the Faculty of Synthetic Biology, Shenzhen University of Advanced Technology. His laboratory is dedicated to investigating gut microbiota-mediated inter-tissue crosstalk and its implications for human health. Specifically, his research elucidates the mechanisms governing the interplay between the gut microbiome and host nutrient metabolism, focusing on their roles in metabolic diseases and translational applications. He has established an integrated "Basic Research-Technology Transfer -Clinical Application" innovation framework. In basic research, the team focuses on profiling the structure and function of gut microbiota and developing microbiome big data analysis technologies. Utilizing multi-omics approaches, they aim to uncover the underlying mechanisms of microbe-host interactions. In clinical research, the team investigates gut microbiota-based intervention strategies (such as probiotics) for metabolic disorders (e.g., obesity, diabetes) and gastrointestinal diseases (e.g., ulcerative colitis). In translational application, Dr. Xie promotes the development of biomanufacturing and health products leveraging microbial fermentation and synthetic biology technologies.

1.Gut microbiome and human health

2.Physiological regulation mechanisms of muscle and adipose stem cells.

3.Trace mineral metabolism and human health

Education

2009-2013 Ph.D. in Nutritional Sciences, Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, USA

2007-2009 B.A. in Molecular and Cellular Biology, Department of Biological Sciences, University of Buffalo, SUNY, Buffalo, NY, USA

2003-2007 B.S. in Automation, School of Electrical and Control Engineering, Xi’an University of Science and Technology, Xian, Shaanxi, P.R. China

Work Experience

1/2026-presnet Associate Professor (Tenured), Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, P.R. China

7/2017-12/2025 Research Professor, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong, P.R. China

05/2014-03/2017 Postdoctoral Fellow, Center for Molecular Medicine, University of Georgia, GA, USA

07/2013-03/2014Postdoctoral Fellow, Molecular & Integrative Physiology, University of Michigan, MI, USA

Publications

1. Q. An, R. Wei, Z. Huang, Y. Tang, M. Wang, S. He, K. Huang, Z. Liu, M. Zhang, R. Li, J. Huang, K. Zhang, J. Ji, L. Xie, Q. Ma. Palmitoylation of Tfr1 enhances platelet ferroptosis and liver injury in heat stroke. Acta Pharmaceutica Sinica B, 2025. https://doi.org/10.1016/j.apsb.2025.10.027

2. B. Liu, Y. Liu, S. Xu, Q. Wu, D. Wu, L. Zhan, Y. Liao, Y. Mai, M. Zheng, S. Wang, Y. Chen, Z. Huang, X. Luo, Z. Xie, X. Pan, G. Yu, L. Xie. EasyMultiProfiler: An Efficient Multi-Omics Data Integration and Analysis Workflow for Microbiome Research. Science China Life Sciences. 2025, In press. doi: 10.1007/s11427-025-3035-0.

3. X. Yao, X. Mai, Y Tian, Y. Liu, G. Jin, Z. Li, S. Chen, X. Dai, L. Huang, Z. Fan, G. Pan, X. Pan, X. Li, M. C. Yu, J Sun, J. Ou, H. Chen, L. Xie. Skeletal Muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders. Science China Life Sciences. 2025 Jan 13. doi: 10.1007/s11427-023-2586-x

4. K. Ding, Z. Zhang, Z. Han, L. Shi, X. Li, Y. Liu, Z. Li, C. Zhao, Y. Cui, L. Zhou, B. Xu, W. Zhou, Y. Zhao, Z. Wang, H. Huang, L. Xie, X. Chen, Z. Chen. Liver ALKBH5 regulates glucose and lipid homeostasis independently through GCGR and mTORC1 signaling. Science. 2025 Feb 28;387(6737):eadp4120. doi: 10.1126/science.adp4120

5. S. Chen, L. Huang, B. Liu, H. Duan, Z. Li, Y. Liu, H. Li, X. Fu, J. Lin, Y. Xu, L. Liu, D. Wan, Y. Yin, L. Xie. Dynamic Changes in Butyrate Levels Regulate Satellite Cell Homeostasis by Preventing Spontaneous Activation During Aging. Science China Life Sciences. 2024, 67, 745–764. doi: 10.1007/s11427-023-2400-3

6. S. Chen, P. Zhang, H. Duan, J. Wang, Y. Qiu, Z. Cui, Y. Yin, D. Wan, L. Xie. Gut microbiota in muscular atrophy development, progression and treatment: New therapeutic targets and opportunities. The Innovation, 2023 Jul 10;4(5):100479. doi: 10.1016/j.xinn.2023.100479

7. L. Huang, G. Pan, Y. Feng, Z. Fan, K. Ma, R. Wang, G. Wang, G. Huang, S. Huang, Y. Hou, M. Huang, L. Xie, Y. Ma. Microbial network signatures of early colonizers in infants with eczema. iMeta.2023 e90. doi: 10.1002/imt2.90

8. H. Ding, S. Chen, X. Pan, X. Dai, G. Pan, Z. Li, X. Mai, Y. Tian, S. Zhang, B. Liu, G. Cao, Z. Yao, X. Yao, L. Gao, L. Yang, X. Chen, J. Sun, H. Chen, M. Han, Y. Yin, G. Xu, H. Li, W. Wu, Z. Chen, J. Lin, L. Xiang, J. Hu, Y. Lu, X. Zhu, L. Xie. Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis. Journal of Cachexia, Sarcopenia and Muscle, 2021 Jun;12(3):746-768. doi: 10.1002/jcsm.12700

9. J. Li, X. Pan, G. Pan, Z. Song, Y. He, S. Zhang, X. Ye, X. Yang, E. Xie, X. Wang, X. Mai, X. Yin, B. Tang, X. Shu, P. Chen, X. Dai, Y. Tian, L. Yao, M. Han, G. Xu, H. Zhang, J. Sun, H. Chen, F. Wang, J. Min and L. Xie. Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes. Advanced Science, 2020 Apr 24;7(12):1903366. doi: 10.1002/advs.201903366

10. L. Xie, A. Yin, A.S. Nichenko, A.M. Beedle, J.A. Call, H. Yin, Transient HIF2a Inhibition Accelerates Muscle Regeneration by Promoting Satellite Cell Proliferation. J Clin Invest. 2018 Jun 1;128(6):2339-2355. doi: 10.1172/JCI96208