Dr. Li Jianjian, Research Assistant Professor, and a Shenzhen “Peacock Plan” Category C Talent.He graduated from The Chinese University of Hong Kong with a PhD in Molecular Biotechnology, and conducted postdoctoral research at the Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, where he received support as a Guangdong Overseas Postdoctoral Fellow. He has long been engaged in research on epigenetic regulation, successively elucidating the regulatory functions and mechanisms of transcription factors(TFs) and non-coding RNAs. Using multi-omics approaches, he studied the evolutionary dynamics of transcription factor regulation in plants, revealing the limited conservation of TF binding sites (cistrome) and the wide-spread cistrome divergence during plant evolution. He systematically summarized the roles of non-coding RNA in mammalian X chromosome dosage compensation, its contribution to sex-biased diseases,and the potential therapeutic applications.He further conducted in-depth multi-omics analyses on the features and mechanisms of non-coding RNA-mediated chromatin regulation in the model organism Drosophila, revealing the functional role and mechanistic basis of sex chromosome dosage compensating RNA in modulating autosomal gene expression. Relevant research has been published in journals such as Nature Communications(2022, 2025), Genes & Diseases, Frontiers in Cell and Developmental Biology.

Education Background

2014-2021, The Chinese University of Hong Kong, PhD in Molecular Biotechnology

2011-2014, Huazhong Agricultural University, Master's in Biochemistry and Molecular Biology

2006-2010, Wuhan University, Bachelor's in Biology (Base Class)

Professional Experience

2024-Present, Research Assistant Professor at Shenzhen University of Advanced Technology

2023-2024, Assistant Researcher at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

2021-2023, Postdoctoral Fellow at Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

Research Projects

1.National Key R&D Program, Youth Scientist Project, Platform Technology for Analysis and Reconstruction of Functional Human Microbial Non-Coding RNA Components, from November 2022 to October 2027, RMB 4,000,000, ongoing, participant

2.National Natural Science Foundation of China, General Project, Research on Intelligent Dynamic Capture and Molecular Markers of iPS Precursor Cells, from January 2023 to December 2026, RMB 540,000, ongoing, participant

Representative Publications

1.Li J†, Xu S†, Liu Z†, Yang L, Ming Z, Zhang R, Zhao W, Peng H, Quinn JJ, Wu M, Geng Y, Zhang Y, He J, Chen M, Li N, Shao NY, and Ma Q*. A noncanonical role of roXRNAs in autosomal epigenetic repression.Nat. Commun.(2025). 16(1): 155.

2.Tu X†, Ren S†, Shen W†,Li J†, Li Y, Li C, Li Y, Zong Z, Xie W, Grierson D, Fei Z, Giovannoni J, Li P* and Zhong S*. Limited conservation in cross-species comparison of GLK transcription factor binding suggested wide-spread cistrome divergence.Nat. Commun.(2022). 13(1): 7632. (†Co-first authors)

3.Li J†, Ming Z†, Yang L†, Wang T, Liu G, and Ma Q*. Long noncoding RNAXIST: Mechanisms for X chromosome inactivation, roles in sex-biased diseases, and therapeutic opportunities.Genes. Dis.(2022). 9(6):1478-1492.

4.Wang T,Li J, Wu M, Yang L, and Ma Q *. The Role of Long Non-coding RNAs in Human Imprinting Disorders: Prospective Therapeutic Targets.Front. Cell. Dev. Biol.(2021). 9:730014.

Utilizing functional genomics approaches (such as transcriptomics, proteomics, and epigenomics) to systematically analyze the epigenetic regulation mechanisms of non-coding RNA, and developing omics research tools suitable for studying non-coding RNA functions.