牟希，深圳理工大学合成生物学院科研助理教授，化学生物学博士。博士毕业于香港城市大学，随后在香港城市大学从事博士后研究。主要从事RNA生物学与化学生物学研究，聚焦RNA结构、长链非编码RNA及RNA–蛋白相互作用，并发展基于mRNA display等技术的功能多肽筛选与RNA靶向策略。相关研究揭示了MALAT1等重要RNA中G四链体的调控功能，并建立高通量RNA–蛋白/多肽互作研究方法。研究成果发表于《Journal of the American Chemical Society》《Nucleic Acids Research》等国际期刊。

1. RNA生物学与RNA–蛋白相互作用

2. 多肽筛选与RNA靶向化学生物学

学习经历：

2018-2023：香港城市大学，化学系，化学生物学专业，博士

2013-2017：西南大学，含弘学院，生物科学专业，学士

工作经历：

2026–至今：深圳理工大学，合成生物学院，科研助理教授

2023–2026：香港城市大学，化学系，博士后

科研项目：

深圳市基础研究专项，2019-2022，结题，参与

代表性论文：

1.Mou, X.*, Wang, J., Shao, Y., Li, Y. *, & Kwok, C. K. * RNA G-Quadruplex Structure Recognition by Bivalent Peptides. Nucleic Acids Res. gkag745 (2026).

* Co-corresponding authors

2.Mou, X.& Kwok, C. K. Peptides Selected by G4-mRNA Display-Seq Enable RNA G-Quadruplex Recognition and Gene Regulation. J. Am. Chem. Soc. 145, 34, 18693–18697(2023).

3.Mou, X., Liew, S. W. & Kwok, C.K. Identification and targeting of G-quadruplex structures in MALAT1 long non-coding RNA. Nucleic Acids Res. 50(1), 397- 410 (2022).

4.Lyu, K. #, Chow, E.Y.C. #,Mou, X.# & Kwok, C.K. RNA G-quadruplexes (rG4s): genomics and biological functions. Nucleic Acids Res. 49(10), 5426-5450 (2021). # Co-first authors

5.Mou, X.& Kwok, C.K. Effect of RNA sequence context and stereochemistry on G-quadruplex-RHAU53 interaction. Biochem Biophys Res Commun. 533(4), 1135-1141 (2020).

6.Zhou, X., Chen, J., Chi, Y.,Mou, X., Zhou, Y., Xie, Q., Sun, H., Taipale, J., Kwok, C.K., Zhang, J., Yan, J., HTRG4-SELEX: a high-throughput platform for charactrization of binding proteins of RNA G-quadruplex structures. Nat. Commun. (Accepted)

7.Zhou, Y, Lyu, S., Liew, S. W.,Mou, X., Hoffecker, I., Yan, J., Li, Y., Kwok, C.K., Zhang, J., MoRNiNG: A Database of RNA Modification Sites Associated with RNA Secondary Structure Dynamics. Genom. Proteome. Bioinf. qzaf106 (2025).

8.Chen, X., Yuan, J., Xue, G., Campanario, S., Wang, D., Wang, W.,Mou, X., Liew, S.W., Umar, M.I., Isern, J., Zhao, Y., He, L., Li, Y., Mann, C.J., Yu, X., Wang, L., Perdiguero, E., Chen, W., Xue, Y., Nagamine, Y., Kwok, C.K., Sun, H., Muñoz-Cánoves, P. & Wang, H. Translational control by DHX36 binding to 5’UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nat. Commun. 12, 5043 (2021).

9.Xu J., Chen Y.,Mou X., Huang Y., Ma S., Zhang L., Zhang Y., Long Q., Ali M.K., Xie J., Mycobacterium smegmatis msmeg_3314 is involved in pyrazinamide and fluoroquinolones susceptibility via NAD +/NADH dysregulation. Future Microbiol. 15:413-426 (2020)

10.Yeung, P.Y., Zhao, J., Chow, E.Y.C.,Mou, X., Hong, H.Q., Chen, L.L., Chan, T.F., Kwok, C.K. Systematic evaluation and optimization of the experimental steps in RNA G-quadruplex structure sequencing. Sci. Rep. 9, 8091 (2019).

11.Ji, D.,Mou, X., Kwok, C.K. Label-free and ratiometric detection of microRNA based on target-induced catalytic hairpin assembly and two fluorescent dyes. Anal. Methods 11, 4808 - 4813 (2019).

专利：

1.Kwok, C. K. & Mou, X., G4-specific peptides and methods of identifying the same. Publication No. US 2024/0255515 A1.

2.Yang D., Feng J., Fan L., Huang M., Xie J., Hu J.,Mou X.& others, Azole derivatives of gatifloxacin and its application, Patent Number: ZL 2019 1 1252190.5