赵勇教授是合成生物学院生物科学系讲席教授。国家杰出青年基金、新世纪百千万人才国家级人才、政府特殊津贴、中科院“百人计划”引进人才、“鹏城孔雀计划”特聘A档获得者。中国免疫学会移植免疫分会副主任委员，中国医药生物技术协会移植技术分会副主任委员。曾任中科院动物所副所长、膜生物学国家重点实验室主任、中国科学院大学存济医学院免疫教研室主任。长期从事移植免疫学研究，主要对移植免疫耐受诱导及其发生细胞分子机制和免疫细胞治疗进行研究，取得一系列重要研究成果。作为首席科学家主持科技部重点基础研究发展计划项目及国家自然科学基金委重点项目等多项科研项目。在Nat Med、Nat Commun、Sci Adv、JEM、Blood、Cell Rep、EMBO Rep及Am J Transplant等发表SCI文章260余篇，中文核心期刊文章70余篇，获得发明专利授权2项。论文引用超17000次。获得爱思唯尔(Elsevier) 2021年-“中国高被引学者(基础医学)”。主编《异种移植免疫学》、《移植免疫耐受》及《合成免疫学》，参编《免疫学前沿进展》等5部书籍。

主要应用器官移植、自身免疫性疾病、肿瘤等动物模型，整合多组学及计算生物学、免疫学、分子生化及合成生物学等技术，开发新型基因编辑免疫细胞药物及生物工程药物，创建可应用于临床治疗的诱导或逆转免疫耐受治疗方案，推动免疫细胞药物在器官移植、自身免疫性疾病及肿瘤治疗中的转化应用。

学习经历：

1990.09-1993.07，吉林大学（原白求恩医科大学），生物学，博士

1987.09-1990.07，吉林大学（原白求恩医科大学），放射医学，硕士

1982.09-1987.07，吉林大学（原白求恩医科大学），放射医学，学士

工作经历：

2022.10-至今，深圳理工大学，讲席教授

2003.04-2022.10,中国科学院动物研究所,研究员/博士生导师

2000.05-2004.04，美国内布拉斯加大学医学中心/医学院外科(免疫学),助教授（tenure track）

1995.07-2000.08，美国哈佛大学/麻省总医院移植生物学研究中心博士后

1993.07-1995.09，日本三菱化成生命科学研究所免疫学研究组,特别研究员（博士后）

国际期刊编委情况：

现为中国生物工程学会、中国免疫学会理事，中国免疫学会移植免疫分会副主任委员，中国医药生物技术协会移植技术分会副主任委员, Cellular & Molecular Immunology、 Expert Review of Clinical Immunology等杂志编委。

国际/国内或研究领域奖项：

1.2024年，中国康复医学会科学技术奖一等奖

2.2023年，“鹏城孔雀计划”特聘A档

3.2021年，爱思唯尔“中国高被引学者(基础医学)”

4.2017年，膜生物学国家重点实验室主任

5.2009年，新世纪百千万人才工程国家级人选

6.2005年，国家杰出青年科学基金

7.2003年，中科院“百人计划”引进人才

成果转化情况：

Wip1抑制剂的医学用途（专利号： ZL2016 1 0165373.3）, 2016（2020获授权）

用于治疗过敏性疾病的长效药物及其活性成分嵌合抗原受体（专利号：ZL 2025 1 0915895.X），2025（2026获授权）

重大科技项目承担情况：

作为首席科学家主持国家重点研发计划项目、国家自然基金重点项目、深圳市医学研究专项资金项目等多项科研项目。

代表性文章：

1.Zhang ZQ, Zhao CX, Sun LY, Lei T, Xu JL, Wang GY*, Zhao Y*. FAM234A acts as a switch for Th17 versus Treg cell fate decision that controls inflammatory bowel disease. Cell and Mol Immunol. 2026. (accepted)

2.Chen YF#, Zhang Q #, Li N#, Zhang ZQ#, Lei T, Guo H, Lu HZ*, Zhao Y*. IL-33/TGF-β/IL-4-induced DC9 subset promotes Th9 differentiation and allergic airway inflammation. Cell Reports. 2026; 45(6): 117519. doi: 10.1016/j.celrep.2026.117519.

3.Su YH†, Jiao AJ†, Zhang XR †, Xu YN †, Ping HX, Zhu K, Wang QH, Yuan N, Gao Y, Ju BM, Ding RY, Wang N, He L, Lei L *, Zhao Y*, Zhang MZ*, Zhang BJ*. Helicase A determines the transcription program of Th17 lineage differentiation and Autoimmunity. Science Advances, 2026, 12(20). DOI: 10.1126/sciadv.aeb9679.

4.Zhao Y, Wang XQ, Lei T, Lu HZ* Zhao Y*. Exploiting the chemokine-chemokine receptor axis: Emerging immunotherapeutic paradigms for solid tumor microenvironment reprogramming. Chinese Medical Journal. 2026, 139(8): 1125-1148.

5.Wang YJ; Yang LJ, Li MY, Hao J, Sun XY, Dong ZJ, Lin L, Hou BD, Zhang Y, Zhao Y, Xu CR, Zhou XY, Jin R, Ge Q. Proenkephalin produced by neonatal T-bet+ Treg cells promotes periportal hepatocyte maturation. Hepatology. 2026, 83(3): 513-529.

6.Ding PB, Lu J, Lei T, Guo YN, Zhu BaL, Zhao Y, Wang Y, Engelstädter J, Schembri Mark A. & Guo JH. Antidepressant drugs promote the spread of broad-host-range plasmid in mouse and human gut microbiota. Gut Microbes. 2025 17(1), 2514138. https://doi.org/10.1080/19490976.2025.2514138.

7.Zhang ZQ #, Xu YN#, Pang K#, Wu CH, Zhao CX, Lei T, Zhang JY, Hai T *, Zhao FQ*, Zhao Y*. Microbiota humanization drives human-like metabolic and immune transcriptomic shifts in pigs. iMetaOmics. 2025. 2(3): e70034.

8.Guo H#, Zhao Y#, Zhang ZQ#, Xu YN, Chen YF, Lei T, Zhao Y*. The presence and pathogenic roles of M(IL-33+IL-2) macrophages in allergic airway inflammation. Allergy. 2025. 80(5): 1298-1308. doi: 10.1111/all.16430.

9.Liu J, Wang MR, and Zhao Y*. The regulatory network of transcription factors in macrophage polarization. ImmunoTargets and Therapy. 2025; 14: 555-575. doi: 10.2147/ITT.S494550.

10.Wei YP, Zu WH, Yang JZ, Wang MR, Zhao Y*. Progression in the in vitro macrophage expansion. Journal of Immunology Research. 2025: 9994439. doi: 10.1155/jimr/9994439.

11.Wei YP, Zhao Y*. De novo thymus reconstitution: the rising of cell-based strategies. International Journal of Immunology. 2025; 13(1): 9-22.

12.Yang H, Ding ZX, An ZL, Zhao Y* & Lu HZ*. Immune checkpoint inhibitor related myositis: an observational, retrospective, pharmacovigilance study. Expert Opinion on Drug Safety. 2025. 24 (12): 1415–1420

13.Li JY; Zeng GD; Zhang ZZ; Wang YL; Shao MY; Li CJ; Lu ZB; Zhao Y*; Zhang F*, Ding WJ*. Urban airborne PM2.5 induces pulmonary fibrosis through triggering glycolysis and subsequent modification of histone lactylation in macrophages. Ecotoxicology and Environmental Safety. 2024. 273(229): 116162. DOI: 10.1016/j.ecoenv.2024.116162.

14.Hou YX*, Wei D*, Zhang ZQ*, Lei T*, Li SH, Bao JM, Guo H, Tan L, Xie XB, Zhuang Y, Lu ZB#, Zhao Y#. Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes. Cell Reports. 2024; 4(1): 113658.

15.Zhang ZQ*, Zhao CX*, Sun LY*, Cheng C, Tian QC, Wu CH, Xu YN, Dong X, Zhang BJ#, Zhang LF#, Zhao Y#. Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoimmune disorder in mice. European Journal of Immunology. 2024. 54(3). 2350836. doi: 10.1002/eji.202350836.

16.Li J*, Xu YN*, Zhang JY*, Zhang ZQ*, Guo H, Wei D, Wu CH, Hai T#, Sun HX#, Zhao Y#. Single-cell transcriptomic analysis reveals transcriptional and cell subpopulation differences between human and pig immune cells. Genes and Genomics. 2024; 46(3): 303-322.

17.Yang H, An ZL, Zhao Y, Lu HZ*. Tacrolimus related acute pancreatitis: An observational, retrospective, pharmacovigilance study. Clinical Therapeutics. 2024. 46(9988). DOI: 10.1016/j.clinthera.2024.04.005

18.Wu CH*, Xu JL*, Zhang ZQ, Wei D, Xu YN, Zhao Y#. The effects of IL-23/IL-18-polarized neutrophils on renal ischemia-reperfusion injury and allogeneic skin graft rejection in mice. Biomedicines. 2023; 11, 3148. https://doi.org/10.3390/biomedicines11123148.

19.Zhao Y*, Zhao CX*, Guo H*, Zhang ZQ*, Xu HW, Sh MP, Xu YN, Wei D, Zhao Y#. mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway. iScience. 2023; 26(9): 107540. doi: 10.1016/j.isci.2023.107540.

20.Chen YF*, Zhao CX*, Zou WL*, Zhang ZQ, Guo H, Lu HZ#, Zhang LF#, Zhao Y#. Wip1 inhibits neutrophil extracellular traps to promote abscess formation in mice by directly dephosphorylating Coronin-1a. Cell Mol Immunol. 2023; 20: 941-954.

21.Zhao CX*, Guo H*, Hou YX, Lei T, Wei D, and Zhao Y#. Multiple roles of the stress sensor GCN2 in immune cells. International Journal of Molecular Sciences. 2023; 24(5): 4285. doi: 10.3390/ijms24054285.

22.Cao LY, Ma LX, Zhao J, Wang XY, Fang XZ, Li W, Qi YW, Tang YK, Liu JY, Peng S, Yang L, Zhou L, Li L, Hu X, Ji Y, Hou Y, Zhao Y, Zhang X, Zhao Y, Zhao Y, Wei YQ, Malik AB, Saiyin He*, Xu JS*. An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo. eLife. 2023; 12: RP86591. DOI: https://doi.org/10.7554/eLife.86591.

23.Lei T#, Zhang JY#, Zhang Qian#, Ma XR, Xu YN, Zhao Y, Zhang LF*, Lu ZB*, Zhao Y*. Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression. Cell Mol Immunol. 2022; 19, 1333–1346.

24.Xu YN#, Zhang ZQ#, Zhao Y#, Zhao CX, Shi MP, Dong X, Zhang JY, Tan L, Zhang LF*, Zhao Y*. TRAPPC1 is essential for the maintenance and differentiation of common myeloid progenitors in mice. EMBO Reports. 2022; e55503. https://doi.org/10.15252/embr.202255503

25.Tian Q*, Zhang Z*, Tan L*, Yang F*, Xu Y, Guo Y, Wei D, Wu C, Cao P, Ji J, Wang W#, Xie X#, Zhao Y#. Skin and heart allo-graft rejection solely by long-lived alloreactive TRM cells in skin of severe combined immunodeficient mice. Science Advances. 2022; 8(4): eabk0270. DOI: 10.1126/sciadv.abk0270

26.Hou YX*, Wei D*, Bossila E*, Zhang ZQ*, Li SH, Bao JM, Xu HW, Zhang LF#, Zhao Y#. FABP5 deficiency impaired macrophage inflammation by regulating AMPK-NF-κB signaling pathway. J of Immunology. 2022; 209: 2181-2191.

27.Hou YX*, Wei D*, Zhang ZQ*, Guo H, Li SH, Zhang JY, Zhang P, Zhang LF#, Zhao Y#. FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism. Cell Reports. 2022; 41, 111668.