毕友坤，深圳理工大学合成生物学院教研助理教授，于中国科学院生物物理研究所完成博士及博士后训练。主要从事衰老状态记忆与可逆性、RNA调控与细胞命运编程、核酸药物与组织再生研究。提出“Senoreverse”衰老逆转策略，揭示细胞衰老状态的可逆潜力；明确miR-302b作为候选核酸药物的转化价值，并面向多种衰老相关适应证推进first-in-class创新药研发。主持国家自然科学基金面上项目、博士后特别资助及国家资助博士后研究人员计划项目，参与国家重点研发计划、北京市自然科学基金交叉融合重点项目等。相关成果发表于Cell Metabolism、Advanced Science 等期刊；获授权中国发明专利4项，提交PCT国际专利申请1项。

1.细胞衰老状态记忆与逆转机制

2.RNA命运调控与细胞状态编程

3.核酸药物与衰老组织再生

学习经历

2019.09-2023.06：中国科学院生物物理研究所，细胞生物学，博士

2015.09-2018.06：西北农林科技大学，预防兽医学，硕士

2010.09-2015.06：西北农林科技大学，动物医学，学士

工作经历

2026.09-至今：深圳理工大学合成生物学院，教研助理教授

2023.07-2026.07：中国科学院生物物理研究所，特别研究助理（博士后）

学术任职

担任The Innovation Life、Chinese Medical Journal 青年编委，并受邀担任Nature Communications、Science Advances 等期刊审稿人。

核心科学发现｜衰老可逆生物学（Senoreverse）

围绕细胞衰老的可逆性，提出“Senoreverse”衰老逆转策略，并通过RNA干预证明衰老细胞可在保持谱系身份的前提下解除增殖阻滞、恢复功能状态。进一步拓展至有丝分裂后细胞及非人灵长类研究，探索其跨细胞类型与跨物种规律。

核心技术发明｜小核酸药物研发与转化体系

构建涵盖分子发现、序列设计、化学修饰、制备质控、递送优化及药效评价的小核酸药物研发体系，并推进其在雄激素性脱发、HIV相关早衰、肌少症及阿尔茨海默病等适应证中的转化应用。

科研项目：

1.国家自然科学基金面上项目（32570714），miR-302b逆转神经元衰老的机制研究，2026.01-2029.12，在研，主持；

2.中国博士后科学基金特别资助（2025T180706），miR-302b对有丝分裂后细胞衰老的干预效果和机制研究，2025.07-2026.07，结题，主持；

3.国家资助博士后研究项目（GZB20230809），胚胎干细胞外泌体对系统性衰老的干预作用和机制研究，2023.09-2025.09，结题，主持；

4.北京市自然科学基金交叉融合重点项目（Z260012），AI和智能体驱动的外周-中枢干细胞抗衰老机制解析及阿尔兹海默症靶向干预研究，2026.07-2030.06，在研，项目骨干。

5.国家自然科学基金面上项目（32470611），增强子RNA在转录调控中的功能机制研究，2025.01-2028.12，在研，项目骨干；

6.国家重点研发计划（2019YFA0110402），人多能干细胞分化心脏谱系的调控及其移植后疗效及安全性研究，结题，项目骨干；

代表性成果：

1.Youkun Bi^#,Xinlong Qiao^#, Zhaokui Cai, Hailian Zhao, Rong Ye, Qun Liu, Lin Gao, Yingqi Liu, Bo Liang, Yixuan Liu, Yaning Zhang, Zhiguang Yang, Yanyun Wu, Huiwen Wang, Wei Jia, Changqing Zeng, Ce Jia, Hongjin Wu^*, Yuanchao Xue^*, Guangju Ji^*. Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells[J].Cell Metabolism, 2025, 37(2): 527-541. e6.

2.Youkun Bi^#, Qun Liu^#, Baohua Zou^#, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue^*, Xuejun Guo5^*, Jianjun Chen^*, Huiwen Wang^*, Guangju Ji^*.Neuron-derived vesicular circMagi1 restrains vascular repair after ischemic stroke by prompting TRIM65-mediated ANXA2 degradation [J].Advanced Science, 2026. (DOI: 10.1002/advs.77808)

3.Youkun Bi^*,Guangju Ji^*,. Cellular senescence as a therapeutic target for aging intervention [J],Biomedical Journal, 2026, 100948. (Invited Review, First & Corresponding Author)

4.Youkun Bi^#, Xinlong Qiao^#, Qun Liu, Shaole Song, Keqi Zhu, Xun Qiu, Xiang Zhang, Ce Jia, Huiwen Wang, Zhiguang Yang, Ying Zhang^*, Guangju Ji^*.Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells[J].Stem Cell Research & Therapy, 2022, 13(1): 449.

5.Youkun Bi, Zhiguang Yang, Meng Jin, Kui Zhai, Jun Wang, Yang Mao, Yang Liu, Mingqin Ding, Huiwen Wang, Fengchao Wang, Hong Cai, Guangju Ji. ERp44 is required for endocardial cushion development by regulating VEGFA secretion in myocardium[J].Cell Proliferation, 2022, 55(3): e13179.

6.Youkun Bi^#, Xuejun Guo^#, Mengqi Zhang^#, Keqi Zhu, Chentao Shi, Baoqi Fan, Yanyun Wu, Zhiguang Yang, Guangju Ji^*. Bone marrow derived-mesenchymal stem cell improves diabetes-associated fatty liver via mitochondria transformation in mice[J].Stem Cell Research & Therapy, 2021, 12: 1-17.

7.Youkun Bi, Lei Gu, Jun Wang, Yan Chang, Meng Jin, Yang Mao, Huiwen Wang, Guangju Ji^*. A Novel system for simple rapid adenoviral vector construction to facilitate CRISPR/Cas9-mediated genome editing[J].The CRISPR Journal, 2021, 4(3): 381-391.

8.Yixuan Liu,Youkun Bi^*,#, Jun Wang, Qi Yuan, Yu Rao, Fengchao Wang, Shiqiang Wang, Guangju Ji^*. Destabilized calcium dynamics visualized using the genetically-coded probe GCaMPJ in intact hearts of Calstabin2-null mice[J].Frontiers in Physiology, 2026, 17: 1787427.(*Co-first author,^*Co-corresponding author)

9. Qun Liu^#,Youkun Bi^#, Shaole Song, Keqi Zhu, Xinlong Qiao, Huiwen Wang, Guangju Ji^*. Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2[J].Stem Cell Research & Therapy, 2023, 14(1): 234. (^#Co-first author)

10. Siyu Yan,Youkun Bi, Qun Liu, Shaole Song, Lihong Ma, Guangju Ji^*. hUC-MSCs Prevent Acute High-Altitude Injury through Apoe/Pdgf-b/p-Erk1/2 Axis in Mice[J].Stem Cell Reviews and Reports, 2025: 1-15.

11. Zhen Ma^#, Ming Li^#, Rui Guo^#, Yu Tian, Yongbin Zheng, Bingxin Huang, Yi You, Qing Xu, Ming Cui, Li Shen, Feng Lan, Hang Yang, Rucong Liu, Tao Yang, Feng Wan, Qihua He, Xiao Huo,Youkun Bi, Yingying Zhang, Yunpeng Ling^*. Treating myocardial infarction via a nano-ultrasonic contrast agent-mediated high-efficiency drug delivery system targeting macrophages[J].Science Advances, 2025, 11(1): eadp7126.

12. Yang Liu^#, Huiwen Wang^*,#, Han Zhang, Jun Wang, Qun Liu,Youkun Bi, Shaole Song, Xinlong Qiao, Keqi Zhu, Yanyun Wu, Guangju Ji^*. CUGBP1, a crucial factor for heart regeneration in mice[J].Cell Death & Disease, 2022, 13(2): 120.

13.Yaning Zhang, Qiwen Zheng, Qili Qian, Na Yuan, Tianzi Liu, Xingjian Gao, Xiu Fan,Youkun Bi,Guangju Ji, Peilin Jia, Sijia Wang, Fan Liu, Changqing Zeng. An integrative polygenic and epigenetic risk score for overweight-related hypertension in Chinese population[J].Genomics, Proteomics & Bioinformatics, 2025, 23(5): qzaf048.