宫瑞，博士。现任深圳理工大学合成生物学院科研助理教授。主要研究方向为基于合成生物学技术的疾病诊断和治疗。1）结合合成生物学、生物传感、电化学技术，研发超灵敏传感器，以提升疾病诊断的灵敏度和准确性；2）通过合成生物学、纳米生物学和细胞调控网络的研究，推动肿瘤精准治疗策略的实现。以第一作者（含共一）和共同通讯作者在J. Am. Chem. Soc.、Nano Lett.、ACS Catal.、Sci. China Life Sci.、Biosens. Bioelectron.、Chem. Sci. 等高水平学术期刊发表论文10余篇。
学习经历：
2018-2021，中国科学院生物物理研究所，博士
2014-2018，中国科学院天津工业生物技术研究所，硕士
2010-2014，山东农业大学,学士
工作经历：
2024—至今，深圳理工大学合成生物学院，科研助理教授
2022-2024，深圳市第二人民医院/中国科学院深圳先进技术研究院，博士后
（所获荣誉）国际/国内或研究领域奖项：
科研项目：
国家自然科学基金青年项目，在研，主持；博士后青年基金面上项目，结题，主持；广东省青年基金项目，在研，主持；深圳市基础研究重点项目，主要成员，在研；深圳市“三名工程”项目，在研，骨干；广州国家实验室专项项目，在研，参与。
代表性文章：
1.Gong Rui; Yang Decai; Zhang Cuijuan; Abbas Ghulam; Miao Beiping; Liang Yueyue; Xu Jianing; Fang Xueyang; Ding Hui; NIR-II Light-Driven Multifunctional Nanozymes PS@CS for Efficient Therapy against Melanoma and Post-tumor Surgery Infection, Nano letters, 2024.
2.Fang Xueyang; Gong Rui; Yang Decai; Li Chenxi; Zhang Yuanyuan; Wang Yan; Nie Guohui; Li Mingle; Peng Xiaojun; Zhang Bin; NIR-II Light-Driven Genetically Engineered Exosome Nanocatalysts for Efficient Phototherapy against Glioblastoma, Journal of the American Chemical Society, 2024.
3.Song Jin; Gong Rui; Song Shibo; Abbas Ghulam; Ma Yaohong; Li Yiwei; The value of electrochemical ratiometry in immunosensing: A systematic study, Biosensors and Bioelectronics, 2025.
4.Wang Jie; Gong Rui; Yang Ming; Wu Xi; Li Ziwei; Huang Haibing; Yan Xiyun; Wang Daji; A ruthenium single atom nanozyme-based antibiotic for the treatment of otitis media caused by Staphylococcus aureus, Frontiers in Chemistry, 2024.
5.Li Ziwei; Gong Rui; Abbas Ghulam; Feng Xiaozhou; Wang Xiaonan; Wang Jie; Huang Haibing; Han Jinghong; Zhang Bairu; Nie Guohui; Dual Phase‐Conversion Strategy Reinforced Otitis Media Therapy Using Metastable Iron Sulfide‐Loaded Thermosensitive Hydrogel, Advanced Therapeutics, 2023.
6.Gong Rui; Yang Chenyang; Abbas Ghulam; Wang Dianbing; Zhang Xianen; Nie Guohui; Ding Hui; Diagnosis of nasopharyngeal carcinoma using an ultrasensitive immunoassay method based on nanoparticles, Nanoscale, 2023.
7.Gong Rui; Wang Dianbing; Abbas Ghulam; Li Shimin; Liu Qian; Cui Mengmeng; Zhang Xian-En; A switch-on molecular biosensor for detection of caspase-3 and imaging of apoptosis of cells, Science China Life Sciences, 2022.
8.Yao Peiyuan; Cong Peiqian; Gong Rui; Li Jinlong; Li Guangyue; Ren Jie; Feng Jinhui; Lin Jianping; Lau Peter C. K.; Wu Qiaqing; Zhu Dunming; Biocatalytic Route to Chiral 2-Substituted-1,2,3,4-Tetrahydroquinolines Using Cyclohexylamine Oxidase Muteins, ACS Catalysis, 2018.
9.Gong Rui; Yao Peiyuan; Chen Xi; Feng Jinhui; Wu Qiaqing; Lau Peter C. K.; Zhu Dunming; Accessing d-Valine Synthesis by Improved Variants of Bacterial Cyclohexylamine Oxidase, ChemCatChem, 2018.
10.Li Guangyue; Yao Peiyuan; Gong Rui; Li Jinlong; Liu Pi; Lonsdale Richard; Wu Qiaqing; Lin Jianping; Zhu Dunming; Reetz Manfred T.; Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N, Chemical Science, 2017.
运用合成生物学、生物传感、纳米生物学和细胞生物学的前沿技术，旨在攻克疾病诊断与治疗领域的关键难题。
