学习经历:
1989年7月至1995年6月,美国加州大学伯克利分校(UCBerkeley),分子细胞生物学,博士;
1988年8月至1989年6月,伊利诺斯大学Urbana-Champaign分校生物化学系;
1983年9月至1987年6月,复旦大学,遗传学,学士。
工作经历:
2022年10月至今,深圳理工大学,杰出教授;
2022年1月至今,中国科学院深圳先进技术研究院,研究员;
2002年9月至2022年1月,清华大学生命科学学院,教授;
1995年7月至2002年7月,美国加州大学旧金山医学院/休斯研究所(UCSF/HHMI),博士后。
国际影响力:
中国生物物理学会微量元素分会副理事长
国际/国内或研究领域奖项:
2007年-2011年,国家杰出青年基金资助
重大科技项目承担情况,代表性文章、成果转化情况:
在研项目:
1.国家重点研发项目《人工真核生物线粒体的合成组装及调控》(2024.12-2029.11),参与,243万元;
2.国家重点研发《智能交互型生物-非生物杂合体系的构建及消化道肿瘤诊疗应用》(2024.01-2028.12),参与,100万元;
3.自然科学基金面上项目《Slc39a13在哺乳动物铁代谢中的作用》,2024.01-2027.12, 在研,主持,50万元。
代表性文章:
(1)Huihui Li, Yanmei Cui, Yule Hu, Mengran Zhao, Kuanyu Li, Xiaoyun Pang, Fei Sun, BingZhou.MammalianSLC39A13promotes ER/Golgi iron transport and iron homeostasis in multiple compartments.Nature Communications,2024, 15(1):10838.
(2)Binyu Lu, Shanshan Guo, Jialin Zhaoi, Xiaoting Wang, Bing Zhou; Adipose knockout of H-ferritin improves energy metabolism in mice.Molecular Metabolism, 2024, 80:101871
(3)Mengjiao Zhong,Bing Zhou.Plasmodium yoelii iron transporter PyDMT1 interacts with host ferritin and is required in full activity for malarial pathogenesis.BMC Biology.2023, 21(1): 279.
(4)Yunpeng Huang, Zhihui Wan, Yinglu Tang, Junxuan Xu, Bretton Laboret, Sree Nallamothu, Chenyu Yang, Boxiang Liu, Rongze Olivia Lu, Bingwei Lu, Juan Feng, Jing Cao, Susan Hayflick, Zhihao Wu, Bing Zhou. Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism.Nature Communications, 2022, 13(1):2412
(5)Guiran Xiao,Mengran Zhao,Zhihua Liu,Fan Du,Bing Zhou.Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster.BMC Biology,2021, 19(1):236.
(6)Guiran Xiao, Zhi-Hua Liu, Mengran Zhao, Hui-Li Wang, Bing Zhou. Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster.Cell Reports, 2019, 26(3): 748-758
(7)Guiran Xiao, Zhihui Wan, Qiangwang Fan, Xiaona Tang, Bing Zhou. The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster.ELIFE, 2014, 3: e03191
(8)Yunpeng Huang, Zhihao Wu, Yu Cao, Minglin Lang, Bingwei Lu, Bing Zhou. Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation.Cell Reports, 2014, 8(3):831-842
(9)Guiran Xiao, Qiangwang Fan, Xiaoxi Wang, Bing Zhou. Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding.Proceedings of the National Academy of Sciences,2013,110 (37):14995-15000
(10)Yue Feng, Wenfei Li, Jian Li, Jiawei Wang, Jingpeng Ge, Duo Xu, Yanjing Liu, Kaiqi Wu, Qingyin Zeng, Jia-Wei Wu, Changlin Tian, Bing Zhou, Maojun Yang. Structural insight into the type-II mitochondrial NADH dehydrogenases.Nature,2012,491(7424):478-482
(11)Zhihao Wu,Yumei Du,Hua Xue,Yongsheng Wu,Bing Zhou. Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production.Neurobiology of Aging, 2012, 33(1):199.e1-12.
(12)Juan Wang, Liying Huang, Jian Li, Qiangwang Fan, Yicheng Long, Ying Li, Bing Zhou. Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation.PLoS one2010, 5 (3):e9582
(13)Wei Li, Weike Mo, Dan Shen, Libo Sun, Juan Wang, Shan Lu, Jane M Gitschier, Bing Zhou; Yeast model uncovers dual roles of mitochondria in the action of artemisinin.PLoS genetics1 (3):e36
(14)Bing Zhou, Shawn Westaway, Barbara Levinson, Monique Johnson, Jane Gitschier, Susan Hayflick. A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.Nature Genetics, 2001, 28(4):345-349
(15)Bing Zhou, Jane Gitschier. hCTR1: A human gene for copper uptake identified by complementation in yeast.Proceedings of the National Academy of Sciences, 1997,94 (14):7481-7486